Topic: pyramidal cell ensembles

Although much work has been devoted to studying the function of molecularly-defined subtypes of GABAergic interneurons in circuits and behaviors, it has been debated if cells belonging to the same molecular and morphological type, for example parvalbumin-expressing basket cells, do homogeneously engage in circuit operations in behaving animals. This can only be studied if the identity of the recorded cell is unambiguously determined. We have established a method to optotag juxtacellularly-recorded neurons in freely-moving rats performing a decision-making task to investigate the operational he