The thermal adjustment used in neuronal biophysical models is wrong: Here is how to fix it
Bahram Pahlavan, Nicolas Buitrago, Fidel Santamaria · COSYNE 2023
There is a substantial effort, and cost, invested towards biophysical modeling of brain networks. Practically all biophysical models of voltage-activated conductances use Hodgkin-Huxley (HH) mechanisms obtained at an experimental temperature and adjusted to a modeling temperature. To do so, all models use the temperature correction factor Q10, which is assumed fixed. By performing an analysis of published data of the reaction rates of sodium, potassium, and calcium membrane conductances, we demonstrate: 1) Q10 is indeed temperature dependent; 2) this relationship is quantitatively and qualitat
Sat, Mar 11, 2023