Topic: quercetin

Quercetin is a polyphenolic flavonoid compound with a proven wide range of biological activities including neuroprotective effects in neuronal injury/neurodegenerative disease models which is related with its high antioxidant properties. However, due to its low water-solubility, poor bioavailability, rapid clearance, instability, and inability to cross the blood–brain barrier (BBB) its potential application for treatment of central nervous system (CNS) disease is limited. Tetrahydroisoquinoline (THIQ) scaffold appears in many drugs’ structures applied in diverse medical applications. Recent re