Lipophenol compounds as new hybrid tools against oxidative and carbonyl stress in Alzheimer’s disease
Otaegui Léa, Jordan Lehoux, Mathieu Vitalis, Laurent Givalois, Thierry Durand, Céline Crauste, Catherine Desrumaux · FENS Forum 2024
Alzheimer’s disease (AD) accounts for 80% of dementia cases worldwide. The major histopathological marker is the presence of extracellular senile plaques composed of beta amyloid peptide aggregates. Beta amyloid peptide accumulation leads to oxidative stress, which through lipid peroxidation induces the formation of reactive carbonyl species (small aldehydes as malondialdehyde, glyoxal or acrolein). These compounds are responsible for carbonyl stress as they form adducts with proteins, lipids and nucleic acids and disturb their functions. Oxidative and carbonyl stress (COS) are thereby therape
ePoster · Neuroscience