Topic: quinpirole

Obsessive-compulsive disorder (OCD) is characterized by persistence and inflexibility in behavior and in thought processes. The putative (in)flexibility in neuronal activation patterns that underlies these pathological behavioral and cognitive symptoms is largely unexplored. We used electrophysiological tetrode techniques to study neuronal activity in anterior cingulate cortex (ACC) and hippocampus in a rat model of OCD based on repeated exposures to D2 and D3 receptor agonist quinpirole. We aimed to characterize spatial and temporal stability in neuronal activation and its relationship to obs