Prenatal alcohol exposure (PAE) leads to dysfunctional formation of excitatory synapses and social impairments in adolescent mice
Elisabetta Gerace, Lucia Caffino, Francesco Resta, Francesca Mottarlini, Beatrice Rizzi, Lorenzo Curti, Alessia Costa, Virginia Sordi, Alessandro Scaglione, Fabio Fumagalli, Francesco S. Pavone*, Guido Mannaioni* · FENS Forum 2024
Background: Prenatal alcohol exposure (PAE) induces a wide range of neurodevelopmental disabilities grouped under the term fetal alcohol spectrum disorders (FASD). The effects of PAE on brain development are dependent on complex long-lasting neurochemical events, including modification of glutamate receptors. Here, we explored whether PAE may affect the functional connectivity and, further, the molecular composition of the glutamatergic synapses in the prefrontal cortex (PFC) of adolescent mice and its effect on social behaviors.Methods: We generated an in vivo model of PAE, by exposing C57Bl/
ePoster · Neuroscience