Rab3 mediates cyclic AMP-dependent presynaptic plasticity and olfactory learning
Aishwarya Aravamudhan, Divya Sachidanandan, Achmed Mrestani, Jana Nerlich, Marius Lamberty, Natalie Hasenauer, Nadine Ehmann, Dennis Pauls, Teresa Seubert, Isabella Maiellaro, Mareike Selcho, Manfred Heckmann, Stefan Hallermann, Robert J. Kittel · FENS Forum 2024
Presynaptic forms of plasticity occur throughout the nervous system and play an important role in learning and memory but the underlying molecular mechanisms are insufficiently understood. Here we show that the small GTPase Rab3 is a key mediator of cyclic AMP (cAMP)-induced presynaptic plasticity in Drosophila. Pharmacological and optogenetic cAMP production triggered concentration-dependent alterations of synaptic transmission, including potentiation and depression of evoked neurotransmitter release, as well as strongly facilitated spontaneous release. These changes correlated with a nanosco
ePoster · Neuroscience