Investigating the role of Rab proteins in mitochondrial dysfunction related to Parkinson’s disease
Martina Brughera, Antonio Auritano, Heather Bondi, Mauro Fasano, Marta Lualdi, Tiziana Alberio · FENS Forum 2024
Mitochondria are dynamic organelles which undergo fusion and fission processes responsible for mitochondrial network rearrangements. When mitochondria are damaged, they are selectively degraded via mitophagy. Collectively, these processes are referred to as “mitochondrial dynamics”, and are dysregulated in Parkinson’s disease (PD). Mutations in mitophagy-related PRKN gene, which encodes the E3 ubiquitin ligase Parkin, have been linked to autosomal recessive juvenile PD. Recently, Rab proteins, molecular players of the endo-lysosomal pathway, have been linked to mitophagy, and mutations in RAB3
ePoster · Neuroscience