Circuit-based framework for fine spatial scale clustering of orientation tuning in mouse V1
Peijia Yu, Yuhan Yang, Olivia Gozel, Ian Oldenburg, Mario Dipoppa, L. Federico Rossi, Kenneth. D. Miller, Hillel Adesnik, Na Ji, Brent Doiron · COSYNE 2023
Recent population imaging studies in mouse primary visual cortex (V1) have revisited and questioned the traditional view of 'salt-and-pepper' organization of orientation tuning preference. A controversy has emerged on whether the organization is truly spatially disorganized, or if there is long-range (~100 μm) or short range (~10 μm) spatial clustering of orientation tuning. We imaged and analyzed the response profile (to orientated gratings) of in vivo populations of layer 2/3 (L2/3) and layer 4 (L4) neurons with a neuropil-free nuclear-targeted GCaMP6s indicator. These datasets provide an un
Sun, Mar 12, 2023