ePoster · Neuroscience
Investigating the association between the novel GAP-43 concentration with diffusion tensor imaging indices in Alzheimer's dementia continuum
Elham Habibzadeh Khiaban · FENS Forum 2024
Background: Synaptic degeneration is one of the pathological events in Alzheimer’s disease (AD), for which growth-associated protein 43 (GAP-43) and diffusion tensor imaging (DTI) could be an indicator. In this study, the CSF GAP-43 clinical trajectories and their association with progression and AD hallmarks with WM micro-structural alterations were evaluated. Methods: A total number of 133 participants were enrolled. GAP-43 and DTI values were compared between groups, both cross-sectionally and longitudinally. Subsequently, the potential of GAP-43 levels in the CSF in predicting DTI values w