Understanding the effects of protons versus x-rays on radiation-induced lymphopenia after brain irradiation: A preclinical study
Julie Coupey, Thao Nguyen Pham, Jérôme Toutain, Viktoriia Ivanova, Erika Hue, Charly Helaine, Ali Ismail, Romaric Saulnier, Gael Simonin, Marc Rousseau, Cyril Moignier, Juliette Thariat, Samuel Valable · FENS Forum 2024
X-ray-based radiotherapy is a standard treatment for brain tumors. However, it is associated with systemic effects like lymphopenia that correlates with poor prognosis. Protontherapy has emerged as a new strategy, given that its ballistic properties (lower entry dose and lack of an exit dose) are exploited to spare healthy brain tissue and reduce side effects caused by systemic inflammation. We investigated how protons could spare circulating leukocytes relative to x-rays and if observed effects could be mediated by ballistic, biologic effects or both. Tumor-free C57BL/6 mice model was used fo
ePoster · Neuroscience