Expression of an immunoglobulin constant domain gene in neurons of the mouse central nervous system
Francesca Pietrafesa, Louis Scheurer, David P. Wolfer, Irmgard Amrein, Sónia Gonçalves Matos, Hanns Ulrich Zeilhofer, Hendrik Wildner · FENS Forum 2024
Immunoglobulins are the first line of defense against pathogens and, as such, it is widely assumed that they are exclusively expressed by B lymphocytes. In a recent study comparing the translatomes of spinal neuron subtypes, we obtained evidence indicating the presence of neuron specific Ighm transcripts encoding only the constant (Fc) but not the variable regions of IgM, in the central nervous system (CNS) of mice. Using in situ hybridization we confirmed prominent expression of Ighm in the spinal cord and found expression in several other CNS areas e.g. deep cortical layers and the hippocamp
ePoster · Neuroscience