Topic: Ras and Rab interactor protein 1

The strength of excitatory synapses is regulated through structural and functional changes, but how they are coordinated at the molecular level is incompletely understood. Ras and Rab interactor protein 1 (RIN1) is a Ras effector protein, that is highly expressed in forebrain excitatory neurons, and loss of RIN1 has been shown to affect synaptic plasticity and learning. Our previous work demonstrated that RIN1 destabilizes synapses and supports postsynaptic AMPA receptor endocytosis during chemical long-term depression. As RIN1 plays a role in enhancing signaling of the tyrosine kinases Abl an