UBE3A-induced ubiquitination changes in the brain reveal the molecular complexity of Angelman syndrome
Nagore Elu Arantzamendi, Unai Alduntzin, Benoit Lectez, Nerea Osinalde, Juanma Ramirez, Natalia Presa, Ugo Mayor · FENS Forum 2024
Angelman Syndrome (AS) is a neurodevelopmental disorder with complex symptomatology caused by the loss of maternal allele expression of one single gene in the brain, the ubiquitin E3 ligase UBE3A. Even if the underlying genetic basis of AS has previously been extensively described, the molecular mechanisms regulated by UBE3A ubiquitination in the brain remain highly elusive. Here we provide the first proteomic report of UBE3A-mediated ubiquitination events in a mammalian brain. In order to identify Ube3a substrates, we have combined our previously described bioUb mouse with a new mouse strain
ePoster · Neuroscience