Melatonin and melatonin-derived H2S-containing compounds act as new Kv7.4 activators
Giorgio Belperio, Paolo Ambrosino, Maria Virginia Soldovieri, Ilenio Servettini, Elisa Magli, Ferdinando Fiorino, Maurizio Taglialatela · FENS Forum 2024
Recent evidence suggests an anti-hypertensive effect for the pineal neurohormone melatonin (MT) as it promotes vasorelaxation through concentration-, receptor-, and vessel-dependent mechanisms. Interestingly, Kv7.4 activation results to be a downstream effect of several vasorelaxants that activate the cAMP signalling cascade. Furthermore, positive modulation of Kv7.4 also appears to be the mechanism by which hydrogen sulphide (H2S) mediates vasorelaxation. In fact, the H2S-donor sodium hydrogen sulphide (NaHS) promoted endothelial-independent relaxations of rat aortic rings by facilitating Kv7
ePoster · Neuroscience