Comparative analysis of biophysical properties of ON-alpha sustained RGCs in wild-type and rd10 retina
Viktoria Kiraly, Molis Yunzab, Francisco Nadal-Nicolas, Steven Stasheff, Shelley Fried, Günther Zeck, Paul Werginz · FENS Forum 2024
Recent studies have shown that ON-alpha sustained (ON-αs) retinal ganglion cells (RGCs) exhibit distinct distribution patterns within the mouse retina, with a notable prevalence observed in the temporal region. RGCs rely mainly on presynaptic inputs to create meaningful outputs, however the contribution of postsynaptic RGC processing is unknown. Therefore, we compared the intrinsic spiking properties of nasal and temporal RGCs in the wild-type and degenerated mouse retina. Whole-cell patch clamp experiments were performed to measure the responses of temporal and nasal ON-αs RGCs in wild-type a
ePoster · Neuroscience