Topic: RE-1 sequence

Repressor-element 1 silencing transcription factor (REST) is a zinc-finger-containing protein that has a vast array of target genes, including those involved in neuronal differentiation, neuronal activity, homeostatic plasticity, neuroinflammation and senescence.Understanding the endogenous mechanisms that control the level of REST is critical, if the protective expression of REST in neurodegeneration or aging were to become the focus of therapeutic approaches. Calcium is a signaling molecule that regulates neuronal activities as well as cellular processes such as autophagy leading to senescen