Upregulation of Stathmin-2 induces microtubule-dependent synaptic modifications during the rewiring of neuronal connectivity
Pablo Martínez San Segundo, David Sedano, Marta Casas, Beatrice Terni, Artur Llobet · FENS Forum 2024
Stathmin-2 (STMN2) is a microtubule-associated protein that promotes microtubule instability and is targeted to vesicles. It is well established that STMN2 is upregulated after injury, however, the biological relevance and the mechanisms activated by a transient increase of STMN2 remain unknown. Using Xenopus tropicalis tadpoles as animal model we observed that STMN2 levels peaked in a population of motoneurons three days after the transection of the spinal cord, before tadpoles recovered their swimming capacity within 5 to 7 days. To investigate the possible role of STMN2 in the process of re
ePoster · Neuroscience