ePoster · Neuroscience
The trial of small molecules to promote re-myelination and neuroprotection in an animal model of demyelination and neuroinflammation
Maurice Pagnin, Rahimeh Emamnejad, Ezgi Ozturk, Danica Nheu, Steven Petratos · FENS Forum 2024
Myelin producing human oligodendrocytes express the main thyroid hormone plasma membrane transporter, monocarboxylate transporter 8 (MCT8). Our group has demonstrated that MCT8 is dysfunctional in conditions of developmental or acquired myelin diseases such as progressive multiple (MS). Small molecules that can bypass MCT8, such as the thyroid hormone analog, diiodothyropropionic acid (DITPA), may improve re-myelination and provide neuroprotection in the central nervous system (CNS), following immune-mediated damage described in a mouse model that mimics MS-like disease.Using the myelin oligod