Unveiling astrocyte dynamics in Parkinson's disease: Insights from single-nucleus profiling across brain regions
Archana Yadav, Zena Chatila, Jason Mares, Xena Flowers, Taekyung D Yun, A.F Teich, Rui M Costa, Phil de hager, Estela-Area Gomez, Gabriela Martins, Roy Acalay, Jean Paul Vonsattel, Vilas Menon, Elizabeth Bradshaw, Serge Przedborski · FENS Forum 2024
Astrocytes, crucial glial cells in the central nervous system, maintain brain function and neuronal health. However, understanding their role and molecular changes in Parkinson's disease (PD) is limited. To illuminate this, we employed single-nucleus profiling across four brain regions: Substantia Nigra (SN), Ventral Tegmental Area (VTA), Substantia Innominata (SI), and Hypothalamus. These regions were selected from 46 donors, each known to manifest diverse PD-related effects, using human postmortem samples. From 46 donors, including 28 sporadic PD and 18 non-PD control (NPC), we obtained 157
ePoster · Neuroscience