Topic: reactive microglia

There is growing evidence that patients with dementia with Lewy bodies exhibit early cortical network excitability and neuroinflammatory changes. To explore the link between the two we have used a transgenic mouse that expresses human mutant alpha-synuclein (hA30P). The study investigated whether there were early pre-symptomatic, neuroinflammatory changes in hA30P mice that could contribute to the network hyperexcitability previously observed.Studies were conducted using 1 month and 2-4 months old hA30P mice of both sexes and compared to age-matched wild-type (WT) mice. Fixed, frozen hippocamp