Exploring the combinatorial, diagnostic utility of multimodal biomarkers in differentially diagnosing Dementia with Lewy Bodies from Alzheimer’s through predictive statistical modelling
Katherine Birditt, Leonidas Chouliaras · FENS Forum 2024
Blood biomarkers are becoming increasingly important for clinical trial stratification and healthcare. Therefore this work explored these existing markers’ diagnostic accuracy and ability to differentially diagnose Dementia with Lewy Bodies (DLB) from Alzheimer’s Disease (AD). A multi-modal, combinatorial approach was taken to validate plasma and PET imaging markers’ utilities.The singular and combined ability of two emerging phospho-tau markers, p-tau217 and p-tau231, to differentiate DLB from AD was tested in a well-characterised cohort of patients over the age of 50. Following from this, pl
ePoster · Neuroscience