Parsing the striatal molecular adaptations in glutamate and dopamine systems in a preclinical model of depression
Marion Violain, Marie-Charlotte Allichon, Vanesa Ortiz, Paula Pousinha, Gwenola Poupon, Stephane Martin, Peter Vanhoutte, Jacques Barik · FENS Forum 2024
Mental disorders are the leading causes of disability worldwide. They comprise a broad range of conditions, including mood disorders, which are in general marked by a significant distress, emotional disturbances, social withdrawal and a loss of interest in normally rewarding activities. Stress is a key environmental factor that predisposes to many mood disorders, such as depression and hinders remission. The behavioral sequelae of stress partly result from enduring changes in striatal dopamine and glutamate transmission. Current therapies primarily target symptoms rather than their causes due
ePoster · Neuroscience