Tropomyosin depletion affects neural cell development, signalling and uptake of pathological proteins
Sian Genoud, Chanchanok Chaichim, Rossana Rosa Porto, Tamara Tomanic, Holly Stefen, Tim Karl, John Power, Thomas Fath · FENS Forum 2024
The actin-cytoskeleton is an essential structural component of all mammalian cells, and involves the constant dynamic cycling between actin monomers and filaments, a process mediated by numerous actin-associated proteins[1]. Tropomyosins are actin-associated proteins that form co-polymers with actin filaments. Here, we aim to determine tropomyosin isoform-specific properties in the brain[2]. We report the expression, localisation and physiological function of various tropomyosin isoforms (and by proxy, their actin filaments) in mouse primary neurons, astrocytes and microglia – with a focus on
ePoster · Neuroscience