Topic: recipient neurons

In several neurodegenerative diseases, commonly referred to as tauopathies, pathological forms of the microtubule-associated protein tau spread in a prion-like manner from donor cells to surrounding (recipient) cells, which clinically correlates with the progressive decline in cognition and cell death. Low density lipoprotein receptor-related protein 1 (LRP1) regulates the endocytosis of tau in neurons and thus its subsequent spread. This LRP1-mediated endocytosis is depended upon regulation of actin. The major regulator of actin filament dynamics is tropomyosin, a family of proteins, shown to