Parallel decrease of synaptic connectivity and unitary synaptic efficacy suggest code transformation in the mouse hippocampal CA3 network during development
Victor Manuel Vargas Barroso, Jake F. Watson, Peter Jonas · FENS Forum 2024
CA3 pyramidal neurons (PNs) in the hippocampus are connected by recurrent collateral synapses, forming the largest auto-associative network in the mammalian brain. How the recurrent connectivity between CA3 PNs is established during development remains unclear. To address this question, we made simultaneous patch-clamp recordings of up to eight CA3 PNs in the mouse hippocampus (7600 tested connections in total). Average connectivity in the mouse hippocampus was down-regulated during development, with apparent average connection probability values of 3.63% (P7–8), 2.41% (P18–22), and 0.94% (P45
ePoster · Neuroscience