Topic: regular spiking cells

Copy number variation in genes associated with glutamatergic transmission have emerged as significant factor in various mental and neurodegenerative disorders. Recent studies have shed light on the role of the GRIK4 gene, which encodes the GluK4 subunit of kainate receptors, in conditions such as autism and schizophrenia. Specifically, de novo duplications of the GRIK4 have been identified in individuals with autism. Overexpression of the Grik4 gene in a mouse model (GluK4over) leads to social deficits, anxiety and depression and has a significant impact on amygdala neuronal excitability, caus