Cell type emergence in the developing medial entorhinal cortex is regulated by Bcl11b
Keagan Dunville, Bianca Ana Zaharia, Kristian Moan, Rajeevkumar R Nair, Clifford G Kentros, Giulia Quattrocolo · FENS Forum 2024
How do neurons in the medial entorhinal cortex (MEC) organize themselves during development to establish networks involved in complex functions like learning and memory? From developmental studies of cortical and subcortical structures, one transcription factor called Bcl11b (encoding Ctip2) is responsible for neuronal differentiation and axonal pathfinding. Interestingly, in the MEC, Bcl11b is expressed by Reelin-positive (Reln+) projection neurons in layers 2 and by intracortical projection neurons in layer 5a . Because Bcl11b is widely expressed by these early born MEC neurons, we hypothesi
ePoster · Neuroscience