Topic: reln cko

The extracellular matrix glycoprotein reelin is best known for orchestrating migration and positioning of cortical neurons during embryonic development. The reeler mutant mouse, lacking reelin expression, displays severe migration defects and aberrant dendritic development of cortical neurons. Less is known about the consequences of postnatally induced reelin deficiency in conditional reelin knockout (reln cko) mice. Postnatally induced reln cko was shown to entail functional deficits of neuronal communication, while morphological deficits of neurons have not been reported so far. Here, we inv