Topic: remifentanil

An influential model of addiction proposes that repeated exposure to addictive drugs results in overvaluation of drug cues and long-lasting cue-drug associations, which results in heightened motivation to seek drugs upon exposure to these cues. This model focuses on the role of midbrain dopamine neurons in forming these associations, known as cue reactivity. However, the neurophysiological responses of non-dopamine neurons to cues predicting opioids vs. natural rewards have not been examined previously. Multi-unit electrophysiological recordings were collected from the midbrain of adult Long-E