Intermittent access to a high-fat diet blocks the increase in ethanol consumption and the neuroinflammatory response induced by social defeat in adult male mice
Carmen Manzanedo, Irene Perez-Esteban, M Carmen Arenas, Hector Cañeque-Rufo2, Esther Gramage, Gonzalo Herradon, Jose Miñarro · FENS Forum 2024
Social stress increases susceptibility to develop substance use disorders, which can be modulated by intermittent exposure to a high-fat diet (HFD). However, both HFD and stress can elevate neuroinflammation levels under specific conditions. The objective of this study was to assess the protective role of intermittent exposure to HFD on the increase in ethanol consumption induced by social stress. The neuroinflammatory response in the hippocampus and the striatum was evaluated by quantitative real-time PCR of several gene expressions. Adult male OF1 mice were exposed to the repeated social def
ePoster · Neuroscience