REST as a target for vision restoration
Dmytro Shmal, Giulia Mantero, Lorenzo Ciano, Giulia Tarricone, Thomas Floss, José Fernando Maya-Vetencourt, Fabio Benfenati · FENS Forum 2024
Repressor Element 1-Silencing Transcription Factor (REST) regulates the expression of a wide array of neuronal genes implicated in differentiation, development and plasticity. We demonstrate the effect of REST inhibition on primary visual cortex (V1) plasticity in the adult mouse. Employing the monocular deprivation paradigm and experimentally-induced amblyopia in a RESTGTi conditional knockout (cKO) model, we studied the effects of stereotaxically delivering Cre recombinase into V1 via adeno-associated virus vectors (AAVs) on visual cortex plasticity in vivo. To this end, we recorded visual
ePoster · Neuroscience