Topic: resective epilepsy surgery

Poor patient outcomes in resective epilepsy surgery remain an area of clinical concern. Regardless of epilepsy type, a third or greater of drug-resistant epilepsy (DRE) patients who undergo resection do not report seizure freedom at a two-year follow-up. One of the likely causes is that current methods for identifying which tissue to resect are subjective and potentially inaccurate. Much of resective surgery planning is based on identification of initial ictogenic tissue--the seizure onset zone (SOZ). However, complete resection of the SOZ, as currently identified, is a poor prognosticator of