Aggression control by type 2 diabetes risk gene Dusp8
Cristina Mencías, Dominik Lutter, H Grallert, C Gieger, Mathias Schmidt, Sonja C. Schriever, Paul T. Pfluger · FENS Forum 2024
Dual-specificity phosphatase (Dusp8) has previously been identified as type 2 diabetes risk gene in humans that is highly expressed in the brain. Dusp8 acts as physiological inhibitor for mitogen-activated protein (MAP) kinases, which are involved in multiple CNS processes. Recently, we reported that hypothalamic Dusp8 acts as rheostat for Janus Kinase (Jnk) 1 in the arcuate nucleus and as critical gatekeeper for hypothalamus pituitary adrenals (HPA) axis functionality, hypothalamic insulin resistance and systemic glucose tolerance. In our follow-up studies, we aimed to dissect whether aberran
ePoster · Neuroscience