Topic: response cumulative distribution function

Mapping the spatial patterns of synaptic connectivity is essential for understanding neural circuit function. Two-photon optogenetics combined with whole-cell patch clamp enable synaptic circuit mapping in mammalian cortex. We consider an experimental set-up in which the experimenter patches a single target cell and uses two-photon optogenetics to stimulate surrounding tissue in a 3-dimensional grid while measuring postsynaptic currents (PSCs). This yields a high resolution spatial map of putative synaptic connections to a single neuron. However, these connectivity maps are noisy due to biolog