Topic: resting state

This talk will focus on the generative modelling of resting state time series or endogenous neuronal activity. I will survey developments in modelling distributed neuronal fluctuations – spectral dynamic causal modelling (DCM) for functional MRI – and how this modelling rests upon functional connectivity. The dynamics of brain connectivity has recently attracted a lot of attention among brain mappers. I will also show a novel method to identify dynamic effective connectivity using spectral DCM. Further, I will summarise the development of the next generation of DCMs towards large-scale, whole-

Neuroimaging recordings during resting state (but also in tasks) reveal that brain-wide functional connectivity networks are highly dynamic, undergoing a structured flow of stochastic-like reconfiguration, with events of transient stabilization of connectivity, intertwined with "leaps" with high and fast variability. Markers of dynamic functional connectivity are increasingly being used as biomarkers of various pathologies and cognitive performance. Here we ask whether there should be some deep reason for Functional Connectivity to be as dynamic as it is observed to be. Functional Connectivit