Topic: resting state activities

Parkinson's disease (PD) is a neurodegenerative disease primarily characterized by severe motor symptoms that can be transiently relieved by medication (levodopa). While there is evidence of widespread alterations of the neuronal activities across the brain, reliable biomarkers are still lacking. To examine this question, we measured the resting state activities of 11 PD patients both with deep stimulation electrodes and with EEG electrodes placed in the motor areas, in order to provide simultaneous recording from both the subthalamic nucleus (STN) and the cortex. Then, we used a dynamical mea