Oxytocin ameliorates aggression in a mouse model of autism spectrum disorder (ASD)
Zhuoni Li, Alexandra Hertz, Eilidh MacNicol, Davide Di Censo, Eugene Kim, Declan Murphy, Michael Craig, Diana Cash, Marija M. Petrinovic · FENS Forum 2024
AimsChallenging behaviours, such as aggression and irritability, are manifested by up to two thirds of autistic individuals. However, despite the detrimental effects challenging behaviours, particularly aggression, have on life of autistic individuals and their families, currently available treatment options are typically borrowed from other areas of psychiatry, and the FDA approved drugs for treatment of ASD-associated irritability are burdened with serious side effects. Therefore, in this study we investigated the effects of oxytocin, a neuropeptide with reported prosocial and anti-aggressiv
ePoster · Neuroscience