Hippocampal neurogenesis changes in a sex and region-specific manner in adult mice subjected to maternal separation as an early life stress
Jose Munoz-Martin, Patricia Chaves-Peña, Maria Inmaculada Infantes-Lopez, Emma Zambrana-Infantes, Andrea Nieto-Quero, Virginia Carayol-Gordillo, Victor Martin-Aguiar, Alejandro Zea-Dona, Carmen Pedraza, Margarita Perez-Martin · FENS Forum 2024
Introduction: Early life stress (ELS) might produce long lasting changes in hippocampal neurogenesis and increase the vulnerability to stress-related disorders later in adulthood. Objective: The analysis of immature granule cell densities in the hippocampal dentate gyrus (DG) between male and female mice subjected to ELS. Methods: Female and male C57BL/6J mice were subjected to 3h daily maternal separation (MS) for 21 days since birth. In day 60, mice underwent a single 2h restriction stress (RS) and sacrificed 24 hours after. The experimental groups were: Control, RS, MS, MS+RS. The DG was an
ePoster · Neuroscience