Network-level disruptions in vulnerable individuals contribute to enhanced fear generalization in a rodent model of PTSD
Robert Daniel Marothy, Gyula Y. Balla, László Szente, Manó Aliczki, Máté Tóth, Éva Mikics · FENS Forum 2024
Posttraumatic stress disorder (PTSD) manifests in some trauma-exposed individuals through excessive fear generalization to safe contexts and difficulties extinguishing fear. While previous studies have implicated functional changes in fear-regulatory nodes a comprehensive understanding of network-wide alterations remains elusive. We employed a rodent model of PTSD to investigate whole-brain activity patterns associated with fear generalization. Male rats underwent uncontrollable footshocks and 28 days later we measured their generalized fear response in an altered/safe context. Based on freezi
ePoster · Neuroscience