Retinal inner nuclear layer thickness in the diagnosis of cognitive impairment explored using a mouse model
Bhavya Chawdhary, Jack J. Maran, Moradeke M. Adesina, Colin R. Green, Andrea Kwakowsky, Odunayo O. Mugisho · FENS Forum 2024
Major neurocognitive disorder (NCD) affects over 55 million people worldwide and is characterized by cognitive impairment (CI). This study aimed to develop a non-invasive diagnostic test for CI based upon retinal thickness measurements explored in a mouse model. Discrimination indices and retinal layer thickness of healthy C57BL/6J mice were quantified through a novel object recognition test (NORT) and ocular coherence tomography (OCT), respectively. Based on criteria from the Diagnostic and statistical manual of mental disorders 5th ed. (DSM-V), a diagnostic test was generated by transforming
ePoster · Neuroscience