Topic: retromer complex

Synaptic dysfunction is an early hallmark of AD pathology. It is characterized by the disruption of synaptic transmission and plasticity. Endosomal trafficking is central to this process. The retromer complex orchestrates the movement of vesicle contents, either pushing them back to the Golgi, degrading them, or recycling them to the plasma membrane. Variations in the cargo recognition component of the retromer, VPS35, have been associated with both Parkinson's (D620N mutation, PARK17) and Alzheimer's (L625P mutation). Extensive pathophysiological studies have been conducted on Parkinson's dis