Transient dopamine depletion increases vesicular glutamate transporter (VGLUT2) expression in midbrain dopamine neurons – implications for Parkinson’s disease
Sivakumar Srinivasan, Thomas Steinkellner, Christian Pifl, Thomas Hnasko, Ellen Gelpi Mantius, Segolene La Batide-Alanore · FENS Forum 2024
Though many neuronal populations are affected in Parkinson’s disease (PD), its cardinal motor symptoms are a consequence of dopamine (DA) neuron loss in the substantia nigra (SNc). The precise mechanisms underlying DA neuron vulnerability remain unclear, but include oxidative stress, and aggregation of alpha-synuclein. More recently, a glutamate driven process has been implicated in disease progression, and there is now proof that DA neurons express the vesicular glutamate transporter VGLUT2 and co-release glutamate. In fact, we discovered that the majority of midbrain DA neurons transiently e
ePoster · Neuroscience