ePoster · Neuroscience
Decoding stress susceptibility from activity in amygdala-ventral hippocampal network
Frances Xia, Valeria Fascianelli, Nina Vishwakarma, Frances Ghinger, Stefano Fusi, Mazen Kheirbek · COSYNE 2023
Fri, Mar 10, 2023
Mood disorders are characterized by behavioral changes arising from network-level alterations, with the amygdala (AMY)-ventral hippocampus (vHPC) pathway being a central component. Anhedonia, the reduced ability to feel pleasure, is a core feature of mood disorders. However, how stress-induced changes in motivation to seek and consume rewards are represented in the activity patterns in the AMY and vHPC remains unclear. Furthermore, how these activity patterns can inform pathway-specific manipulations to rescue anhedonic behavior remains to be explored. Here, we used Neuropixels probes to recor