Topic: Reward Prediction Error (RPE)

Aims: Decision making relies on cognitive maps of available options and expected outcomes. The dopaminergic (DA) system can encode such expectations, and discrepancies between expected and actual outcomes, the so-called Reward Prediction Error (RPE). Here we addressed the link between decision strategies, contingency representation and RPE.Methods: In a circular arena with three locations associated with rewards, mice are conditioned to perform sequences of binary choices. To promote shifts in decision strategy and the associated neural representation of actions, we used exactly the same setti