The gut-brain vagal axis governs mesolimbic natural and recreational reward dynamics
Oriane Onimus, Tinaig Le Borgne, Faustine Arrivet, Julien Castel, Philippe Faure, Nicolas Heck, Fabio Marti, Serge Luquet, Giuseppe Gangarossa · FENS Forum 2024
Reward-related disorders, elicited by recreational psychoactive drugs (cocaine, amphetamine) or natural rewards (food), are associated with functional, structural and long-lasting alterations of the brain dopamine (DA) reward system. Despite their intrinsic differences, drugs of abuse and palatable food lead to (mal)adaptive modifications of the DA system that can ultimately drive compulsive and addictive behaviours with severe health and social impacts, collectively increasing the urgent need for innovative therapeutic strategies.Visceral and interoceptive information through the vagal axis,
ePoster · Neuroscience