Neonatal handling age-dependently modulates social interaction, prepulse inhibition, and frontocortical expression of synaptic and neuroplasticity markers in a genetic rat model of schizophrenia-relevant features
Natalia Peralta, Toni Cañete, Daniel Sampedro-Viana, Adolf Tobeña, Ignasi Oliveras, Cristóbal Río-Álamos, Susana Aznar, Alberto Fernández-Teruel · FENS Forum 2024
We investigated the potentially positive neurodevelopmental and enduring effects of neonatal handling (NH) on specific behavioral processes and gene expression in the prefrontal cortex of RHA versus RLA rats. Additionally, we explored associations between gene expression and behavioral responses. Male rats from both the RLA and RHA strains received NH or were left untreated (controls). Two different age groups were considered: adolescent and adults. The assessment encompassed exploratory behavior, social behavior, sensorimotor gating (PPI), and the analysis of gene expression associated with s
ePoster · Neuroscience