Epileptic activity induces rapid ROCK1-dependent astrocyte morphology changes
Petr Unichenko, Stefanie Anders, Björn Breithausen, Michel K. Herde, Daniel Minge, Adlin Abramian, Charlotte Behringer, Tushar Deshpande, Anne Boehlen, Cátia Domingos, Lukas Henning, Julika Pitsch, Young-Bum Kim, Peter Bedner, Christian Steinhäuser, Christian Henneberger · FENS Forum 2024
Long-term changes of the morphology and function of astrocytes are well known to occur in epilepsy and are thought to play an important role in the development and manifestation of the disease. However, the initial astrocytic processes triggered at the onset of status epilepticus or epileptiform activity are less clear. For instance, it remains to be established how quickly epileptic activity induces changes of astrocyte morphology and what the associated molecular cascades is.We used two-photon excitation fluorescence imaging to monitor changes in astrocyte morphology concurrently with the in
ePoster · Neuroscience