Topic: Rho GTPase-activating protein

Intellectual Disability-Autism spectrum disorder (ID-ASD) are complex neurodevelopmental diseases characterized by a wide spectrum of deficits in cognitive, social and adaptive functions. Among the X-linked gene associate to ASD-ID, OPHN1 encodes a Rho GTPase-activating protein (Rho-GAP) expressed in neurons and non-neuronal cells, during development and in adulthood, in brain areas with a high degree of plasticity, such as the cortex, the hippocampus, and the olfactory bulb (OB). Several evidence indicate that part of the ID-ASD pathology can be ascribed to defects in synaptic morphology and