Identification of excitatory presynaptic neurons participating in regulation of noradrenergic neurons in the locus coeruleus
Hsiu-Wen Yang, Yun Chang, Chao-Cheng Kuo, Ming-Yuan Min · FENS Forum 2024
Noradrenergic (NA) neurons in the locus coeruleus (LC) play a critical role in behavior by supplying norepinephrine to the brain. Understanding how LC-NA neurons are regulated is essential to understanding the role of the LC-NA system in behavior. Since previous studies have identified a population of inhibitory pre-LC neurons that regulate LC-NA neurons, this study investigates whether there are excitatory pre-LC neurons responsible for the regulation of LC-NA neurons. We infused AAVs into the LC of TH-Cre crossed with vGluT2-FLP mice expressing wheat germ agglutinin (WGA) and eYFP in a Cre-
ePoster · Neuroscience